What is Tangential Flow Filtration?

Tangential flow filtration, also named cross-flow filtration, is a process of separation, extensively utilized in food and biopharmaceutical industries. It is diverse from other filtration systems in that the fluid is conceded parallel to the filter, rather than being pushed via membrane upright which can clog the filter media.

This technique is popular for its constant filtration and reproducible performance. The elements that passed by the membrane, the infuse, are put off to the side, whereas the rest, the retentate, is recycled. The tangential flow filtration market is experiencing growth and is projected to be USD 3,667.2 million market by 2030.

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When is Tangential Flow Filtration used?

TTF is majorly utilized in diafiltration and concentration processes.

• Concentration – It surges the concentration of a solution by eliminating fluids while keeping the solute molecules. This method is done by picking a filter suggestively smaller than the solute molecules to enable better preservation of solute molecules.

• Diafiltration – The separation of large and small elements, parting the smaller particles behind without changing the complete concentration at the end by washing out the residual salt with another buffer. This procedure can also decrease the concentration of a solution by washing out the residual salts with water.

Types of Tangential Flow Filtration

Microfiltration- Is utilized in the initial stages of downstream processing for the recapturing or isolation of bio-product away from bioreactor waste material and micro-particulates. Microfiltration aid in elucidating the feed in the upstream harvest. Microfiltration can be utilized in separating microorganisms and deferred particles ranging from .1 to 9 μm in size.

Ultrafiltration- Can be utilized in the middle phase of the downstream process, preceding distillation chromatography. At this time, ultrafiltration is an effective process for buffer and protein concentration exchange preceding the polishing chromatography phase. Ultrafiltration splits macro-molecules ranging from 0.001 to 0.1 μm in size.

Nanofiltration- This is one existing technique for end-process sterilization. Nanofiltration is used to sterilize the ultrafiltration retentate from viruses and microbes and eliminate insoluble proteins in preparation for filling and formulation. Nanofiltration splits molecules that range from 1-10 nanometres in size.

Which filtration technique is best?

Reverse Osmosis Systems- These are most appropriate for domestic use and offer a highly effective way to purify your drinking water. Progressively, such systems are also used in hospitality settings to purify water made for coffee as they provide the finest level of filtration existing.

Advantages of Tangential Flow Filtration

Normal Flow Filtration permits filter cake to gather on the surface of the filter which can source fouling of the membrane. Tangential flow filtration constrains the fouling process by constantly sweeping the membrane surface, maintaining the membrane pure to perform its separating function.

This surges the period that a filter unit can be operative and it is an advantage that can be leveraged to fit a constant manufacturing process for larger-scale production units.

Hence, tangential flow filtration systems are a multipurpose and effective solution for almost any form of purification, filtration, and explanation at any phase of the bioproduction train, such major reasons will drive the tangential flow filtration market in the future as well.